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During deep sleep: Growth hormone secretion peaks, driving tissue repair and muscle recovery The brain’s glymphatic system clears metabolic waste products, including proteins associated with neurodegeneration Cortisol levels reach their daily minimum, allowing the adrenal system to reset Immune function regenerates Cellular repair mechanisms run at maximum efficiency Most adults spend less time in deep sleep than optimal, and this deficit increases with age, stress, alcohol consumption, and certain medications

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What is still open: FDA is accepting written comments through July 22 under docket FDA-2025-N-6895 at regulations.gov, and those comments go to the agency as it finalizes its decision after the meeting.⁵ A committee recommendation is not a final rule