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[DOI] [PMC free article] [PubMed] [Google Scholar] 190.Whittle B.J., Boughton-Smith N.K., Moncada S

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Interestingly, PNPLA3 I148M is not properly targeted by the UPS which likely promotes the disease-causing variant to accumulate on LDs (135) where it can disrupt protein-protein interactions critical for TAG hydrolysis (70, 75)