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Mathematical modeling results showed increased fat metabolism, decreased glucose metabolism, and increased synthesis/turnover of NAD+, carnitine, and glutathione.⁽¹²⁾ Ninth Human Niagen Study That Demonstrates Effectiveness: An ex vivo and pilot clinical study published in the Journal of Clinical Investigation investigated mitochondrial dysfunction in peripheral blood mononuclear cells (PBMCs, or white blood cells)

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When aged rats received Dihexa, their cognitive performance improved toward levels seen in younger animals