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Synthetic biology techniques, such as gene editing and genetic engineering, can greatly improve biological activity and deliver MOTS-c directly to the acting site, thus further expanding the therapeutic application of MOTS-c
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Egan G, Kumar A, Voisin V, Hurren R, Chegini A, Ling D, Thomas G, Yan Y, Feng Y, Duong N, Khan D, Sarathy C, Bansal S, Zeng A, Hoff F, Kornblau SK, Dick J, Hitzler J, Schimmer A Ribosome biogenesis and its regulation by the exportin, CSE1L, are targetable vulnerabilities in childhood and young adult Acute Myeloid Leukemia, 2025