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It is shown to raise in chronic infectious diseases like tuberculosis, lepra, in autoimmune diseases like RA and systemic lupus erythematosus, in kidney transplant rejection, benign monoclonal gammopathy and malign diseases [17, 37]

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This suggests that NP4 could effectively promote the polarization of M2-type macrophages towards M1-type macrophages, thereby alleviating immune suppression