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Melanotan 2 is a cyclic heptapeptide — retaining only the central seven-residue pharmacophoric core of the Melanotan 1 sequence, cyclised through an intramolecular Asp–Lys lactam bridge — which eliminates the flanking residues that provide MT-1’s MC1R selectivity and produces non-selective activation across MC1R, MC3R, MC4R, and MC5R simultaneously

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& van Ree, R