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Examples of the dependency of chemopreventive agents on Nrf2 to inhibit chemical carcinogenesis in the mouse are provided by the protection conferred by oltipraz against benzo[ a ] pyrene-initiated stomach cancer, through induction of Gst and Nqo1 , and protection conferred by oltipraz against N -nitrosobutyl (4-hydroxybutyl)amine bladder carcinogenesis, through induction of Ugt1a [363–365]

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Then, one or two times per month for maintenance