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The 5′-UTR mutation of the human HR gene causes a rare autosomal dominant alopecia disease: Marie Unna hereditary hypotrichosis (MUHH), which is characterized by an abnormal hair density on the scalp, eyebrows, eyelashes, or body

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Estrogen can also impact mitochondrial biogenesis, function, and regulation of ATP production.[ref] In a nutshell, estrogen causes the body to increase the production of other hormones, growth factors, and metabolic factors