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Estrogen shapes how muscle repairs and how the body handles growth signals, and the menstrual cycle phase can shift recovery and inflammatory markers, so the same study run in week one and week three can read differently

CHDOCS

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Since the liver is the major source of IGF and IGFBP production, they examined whether levels of IGFs (IGF-1 and IGF-11) and IGFBPs (IGFBP-1 and IGFBP-3) differed when insulin was infused into the portal or peripheral vascular system [13]