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Structurally characterized by up to four BCL-2 homology (BH) domains that govern protein interactions, the BCL-2 protein family is divided into three functionally opposing categories: multi-domain pro-survival members (e.g., BCL-2, BCL-XL, MCL-1), which inhibit apoptosis by sequestering BH3-only initiators (such as BIM, PUMA) and multi-domain effectors (BAX/BAK)

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But smokers that had the high level, like smokers that were taking their fish oil or eating fish or whatever it was they were doing to get them up to 8%, they had the same life expectancy as nonsmokers with the low omega-3 index