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In humans, GSH levels can be assessed in the brain in vivo using magnetic resonance spectroscopy (MRS), a powerful non-invasive technique for cerebral metabolite quantification, as well as in autopsy brain tissue and peripheral blood using biochemical assays, such as high-performance liquid chromatography (HPLC) (Asensi et al., 1994)

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The published research on oral B12 bioavailability consistently shows around 1% absorption — meaning of a 1000mcg oral dose, only about 10mcg actually reaches your cells