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Furthermore, evidence suggests that depression may precede the clinical diagnosis of IBD by years, pointing toward shared early-life risk factors and a bidirectional pathophysiological link (Di Vincenzo et al., 2025)

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Funding This work was supported by JST CREST Grant Number JPMJCR2024 (20348438 to T.A.), a Grant-in-Aid for Challenging Exploratory Research (22K19397 to T.A.), a Grant-in-Aid for Scientific Research on Innovative Areas (A) “Sulfur biology” (21H05263 to T.A., 21H05267 to T.S., and 21H05258 to T.A