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A better understanding of the complex physiology of weight regulation and the role of intestinal hormones in regulating food intake, appetite, and glucose homeostasis led to the discovery of GLP- 1 receptor analogs as safe and effective treatments, initially for T2DM and more recently in higher doses to treat obesity (liraglutide 3 mg and semaglutide 2.4 mg)

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TRANSITION FROM INTESTINAL HOMEOSTASIS TO LEAKY GUT SYNDROME Leaky gut syndrome emerges when oxidative and inflammatory stress disrupt tight junction structure and regulation