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These synergy studies established the mechanistic principle underpinning the GHRH analogue + GHS-R1a agonist combination format — demonstrating that dual-pathway somatotroph co-stimulation is not merely additive but produces signal amplification through convergent intracellular mechanisms

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Together, these compounds improve the maturation rate of oocytes and the cleavage rate of embryos (Maddahi et al., 2024)