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A brain-to-small intestine circuit mediates morphine-induced constipation in male mice | Nature Communications

Community Buzz 5-Amino-1MQ (just called “5-amino” or “1MQ” in forums) is often described as the “fat cell shrinker.” It’s technically a small molecule, not a peptide — something the community constantly points out — but it’s sold alongside peptides and loved for one big reason: it blocks the NNMT enzyme that makes fat cells store energy instead of burning it

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But how, you ask