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TOS was markedly elevated in IR group compared with SHAM group ( p = 0.0019), while the increase relative to B group did not reach statistical significance ( p = 0.0960)

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In addition to the canonical CoQ biosynthetic enzymes, recent studies have revealed that reticulon 4-interacting protein 1 (RTN4IP1), a mitochondrial matrix protein, participates in CoQ 9 biosynthesis by regulating the activity of COQ3 34