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Its defining physicochemical feature is resistance to hydrolysis at low pH, unusual for a peptide of this length and attributed to a proline-rich, conformationally constrained backbone carrying three consecutive prolines plus a fourth at position eight

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doi: 10.1016/j.fertnstert.2011.07.928 226 FlorouPAnagnostisPTheocharisPChourdakisMGoulisDG