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Additional information Supplementary Information accompanies the paper on the Translational Psychiatry website Supplementary information Rights and permissions This work is licensed under the Creative Commons Attribution-NonCommercial-No Derivative Works 3.0 Unported License

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The toxicity may be enhanced, perhaps synergistically, by oxidative stress and by Michael adduction between aminoacrylate and susceptible nucleophiles such as GS − and protein sulfhydryls and/or by modification of coenzyme in susceptible PLP enzymes