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A recent meta-analysis of 29 trials highlighted the impressive efficacy of first-generation vaccines, showing that the combined efficacy of a full course of vaccination against hospitalization was greater than 95% [5]
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, in a prospective study, examined 493 RYGB patients and confirmed that after one year of follow-up with evaluation moments every three months and treatment with 1000 μg intramuscular cyanocobalamin, only 3.6% of cases were reported as vitamin B12 deficient.[44] In another study conducted by Brolin RE et al