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Other studies emphasize this connection by showing positive correlation between elevated IL-6 level and increased severity of COVID-19, such as exacerbated respiratory failure, hypercytokinemia and rapid progression to acute respiratory distress syndrome (ARDS) [11,71]

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Chronic low-grade inflammation, often called "inflammaging," is now recognized as a central driver of biological aging, contributing to cardiovascular disease, neurodegeneration, insulin resistance, and loss of muscle mass