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Purificação: A cadeia peptídica cortada passa por tratamento de purificação para remover impurezas

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Patient mutations in VARS reduce aminoacylation activity To evaluate the impact of variants on protein stability and function, we collected skin punches then generated primary fibroblast cultures from an affected member of four of the families, as well as parental healthy controls (obligate carriers) in three families, and compared with results from cultures from unrelated healthy controls