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In the foundational rodent work, dihexa reversed scopolamine-induced deficits in the Morris water maze at the top dose of every route tested, improved performance in 24-month-old aged rats, and produced roughly a threefold increase in dendritic spine density in hippocampal culture (41 versus 15 spines per 50 micrometres), with wider spine heads (0.80 versus 0.67 micrometres) and confirmation via AMPA-receptor miniature EPSCs that the new spines were functionally wired rather than morphological artifacts

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