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But when histamine levels build up faster than the body can break them down, it can lead to issues such as: Chronic itching and skin irritation Digestive upset (diarrhea, vomiting, gas) Respiratory issues (sneezing, congestion) Hyperactivity or anxiety-like behaviors If you’ve tried changing your pet’s diet, eliminating allergens, or using medications without success, histamine intolerance might be the missing piece of the puzzle