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Secondary antibody, 1 :3000 Alexafluor 488 goat-anti-mouse (Invitrogen: Carlsbad, CA) was applied for two hours at room temperature

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Types of EDS Hypermobile EDS (type 3 hEDS) – this type of ehlers danlos syndrome is characterized primarily by joint hypermobility affecting both large and small joints, which may lead to recurrent joint pain, joint dislocations, and subluxations (partial dislocation) Classical EDS (type 1 cEDS) is associated with extremely elastic (stretchy), smooth skin that is fragile and bruises easily