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To evaluate whether combining distinct immune signals could enhance tumor cell killing, we tested whether co-administration of T cell engagers (signal 1) with either co-stimulatory (signal 2) or cytokine (signal 3) payloads could function in an “AND” gate configuration (Fig

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[DOI] [PMC free article] [PubMed] [Google Scholar] 218.Rutherford G., Manning P., Newton J.L