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It suppresses ECM degradation, counteracts RSL3 mediated inhibition of GPX4, increases intracellular GSH levels and the GSH/GSSG ratio, reduces MDA content, and inhibits activation of the MAPK/NF-KB pathways, thereby protecting chondrocytes from ferroptosis (156)

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Using the clinical trial escalation protocol (2mg starting dose with 2mg increases every 4 weeks), reaching the 12mg maintenance dose takes approximately 20 weeks