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Nonclinical studies in rodents of clinically relevant doses of GLP-1 receptor agonists showed dose-related and treatment-duration-dependent increases in the incidence of thyroid C-cell tumors (adenomas and carcinomas)

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Mechanistycznie obie cząsteczki wiąże pochodzenie od układu Ang-IV/IRAP, jednak dla Dihexy centralnym proponowanym mechanizmem efektu prosynaptycznego jest augmentacja osi HGF/c-Met

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