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As discussed in this review, in many pathophysiological conditions GPx1 plays a protective role and excess GPx1 can attenuate disease development and progression, however, evidence also suggests that the role of GPx1 can differ in other cellular contexts

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Women are nearly twice as likely to develop anxiety disorders, potentially due to enhanced HPA axis activation under stress and modulatory effects of sex hormones on GABAergic and glucocorticoid signaling (Jaggar et al., 2020)