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In this critical review, we will highlight the most relevant aspects of this recently described mechanism, which has been studied little in epilepsy, its impact on the prognosis of the disease, and its effects on the development of central and/or peripheral comorbidities, including SUDEP (sudden unexpected death in epilepsy)

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Hence, the data in our current work is consistent with other reports [7,32,39,42,58,59], suggesting that PHWE is an environmentally friendly and likely to be a cost-effective technique for the extraction of natural products that are biologically active