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Natural matrices include chitosan, gelatin, cellulose, and hyaluronic acid, whereas synthetic options include poly(N-isopropylacrylamide), poloxamers, and polyethylene-glycol–based systems ( Radioactive synovial repair (RSO) delivers radioisotopes intraarticularly so that emitted β radiation suppresses synovial hyperplasia and limits collateral cartilage and bone damage (Kampen et al., 2022)