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GHK-Cu treatment reduced reactive oxygen species (ROS) production, increased superoxide dismutase (SOD) activity, and decreased TNF-α and IL-6 production by inhibiting NF-κB p65 and p38 MAPK signaling in LPS-induced macrophages and ALI models

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Leveraging the available RAF-selective pharmacophores, they created two BOLT ligands: AZ13-tet containing the AZ628 pharmacophore and AZ181-tet containing the PLX4720 pharmacophore, which are significantly distinguished from the previous iBOLT ligands 279 with photoisomerizable linkers